Dimitrios Tsikas Selected Research

N,N-dimethylarginine (asymmetric dimethylarginine)

6/2019	Distinct associations between plasma osteoprotegerin, homoarginine and asymmetric dimethylarginine in chronic kidney disease male patients with coronary artery disease.
3/2019	Development and validation of GC-MS methods for the comprehensive analysis of amino acids in plasma and urine and applications to the HELLP syndrome and pediatric kidney transplantation: evidence of altered methylation, transamidination, and arginase activity.
1/2018	Inverse correlation between maternal plasma asymmetric dimethylarginine (ADMA) and birthweight percentile in women with impaired placental perfusion: circulating ADMA as an NO-independent indicator of fetal growth restriction?
9/2015	Plasma homoarginine, arginine, asymmetric dimethylarginine and total homocysteine interrelationships in rheumatoid arthritis, coronary artery disease and peripheral artery occlusion disease.
9/2015	The L-arginine/NO pathway and homoarginine are altered in Duchenne muscular dystrophy and improved by glucocorticoids.
9/2015	Plasma ADMA associates with all-cause mortality in renal transplant recipients.
9/2015	Asymmetric dimethylarginine (ADMA) in human blood: effects of extended haemodialysis in the critically ill patient with acute kidney injury, protein binding to human serum albumin and proteolysis by thermolysin.
10/2014	Plasma homoarginine (hArg) and asymmetric dimethylarginine (ADMA) in patients with rheumatoid arthritis: is homoarginine a cardiovascular corrective in rheumatoid arthritis, an anti-ADMA?
11/2012	Clinical-chemistry laboratory relevant hemolysis is unlikely to compromise human plasma concentration of free asymmetric dimethylarginine (ADMA).
8/2012	Increased asymmetric dimethylarginine (ADMA) dimethylaminohydrolase (DDAH) activity in childhood hypercholesterolemia type II.

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Dimitrios Tsikas Research Topics

Disease

8	Hypertension (High Blood Pressure) 11/2021 - 04/2002
8	Coronary Artery Disease (Coronary Atherosclerosis) 06/2019 - 11/2005
7	Atherosclerosis 07/2018 - 08/2004
6	Cardiovascular Diseases (Cardiovascular Disease) 04/2020 - 12/2003
6	Body Weight (Weight, Body) 03/2017 - 08/2004
5	Rheumatoid Arthritis 09/2022 - 11/2011
4	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 06/2022 - 09/2015
4	Heart Failure 10/2021 - 08/2008
4	MELAS Syndrome (Syndrome, MELAS) 01/2018 - 11/2016
4	Inflammation (Inflammations) 12/2015 - 09/2005
4	Myocardial Infarction 05/2009 - 04/2006
3	Takotsubo Cardiomyopathy 04/2022 - 12/2013
3	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2022 - 09/2015
3	Overweight 06/2019 - 09/2015
3	Chronic Renal Insufficiency 06/2019 - 10/2016
3	Pre-Eclampsia (Preeclampsia) 01/2018 - 05/2003
3	Peripheral Arterial Occlusive Disease 1 09/2015 - 01/2003
3	Obesity 09/2015 - 05/2014
3	Type 2 Diabetes Mellitus (MODY) 04/2015 - 04/2005
3	Hemolysis 11/2012 - 04/2009
3	Hypercholesterolemia 08/2012 - 02/2004
3	Neoplasms (Cancer) 04/2011 - 04/2009
2	Hyperlipidemias (Hyperlipidemia) 04/2022 - 12/2015
2	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 02/2022 - 01/2020
2	Cystic Fibrosis (Mucoviscidosis) 11/2020 - 06/2020
2	Lung Diseases (Lung Disease) 06/2020 - 01/2012
2	Infections 06/2019 - 06/2009
2	Kidney Diseases (Kidney Disease) 03/2019 - 02/2009
2	Erectile Dysfunction 02/2019 - 11/2002
2	Dyslipidemias (Dyslipidemia) 07/2018 - 05/2016
2	Dehydration (Water Stress) 01/2018 - 01/2016
2	Ischemia 01/2017 - 09/2015
2	Pulmonary Edema 01/2016 - 08/2008
2	Hypercapnia 01/2016 - 05/2013
2	Weight Loss (Weight Reduction) 09/2015 - 01/2014
2	Albuminuria 09/2015 - 08/2011
2	Hyperoxia 01/2015 - 09/2012
2	Pulmonary Hypertension 12/2012 - 04/2009
2	Rheumatic Diseases (Rheumatism) 05/2011 - 11/2009
2	End Stage Liver Disease 02/2009 - 05/2007
2	Infarction (Infarctions) 08/2008 - 04/2006
2	Diabetes Mellitus 05/2004 - 02/2004
2	Chronic Kidney Failure (Chronic Renal Failure) 01/2004 - 10/2003

Drug/Important Bio-Agent (IBA)

27	Arginine (L-Arginine)FDA Link 04/2022 - 01/2003
26	Nitric Oxide (Nitrogen Monoxide)FDA Link 09/2022 - 08/2003
21	NitritesIBA 02/2022 - 09/2005
20	N,N-dimethylarginine (asymmetric dimethylarginine)IBA 06/2019 - 05/2003
16	NitratesIBA 02/2022 - 08/2004
13	HomoarginineIBA 04/2022 - 05/2014
10	Nitric Oxide Synthase (NO Synthase)IBA 10/2018 - 12/2003
6	Biomarkers (Surrogate Marker)IBA 04/2022 - 04/2009
6	Proteins (Proteins, Gene)FDA Link 06/2019 - 08/2008
6	CreatinineIBA 06/2019 - 05/2007
4	CitrullineIBA 06/2022 - 12/2006
4	Lysine (L-Lysine)FDA Link 04/2022 - 06/2019
4	S-NitrosothiolsIBA 07/2018 - 11/2002
4	Carbonic Anhydrases (Carbonic Anhydrase)IBA 01/2018 - 04/2015
4	Biological ProductsIBA 01/2018 - 08/2004
4	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA 10/2013 - 05/2003
4	erucylphosphocholineIBA 11/2007 - 11/2005
3	Malondialdehyde (Propanedial)IBA 09/2022 - 01/2010
3	Amino Acids FDA Link 04/2022 - 12/2015
3	symmetric dimethylarginineIBA 01/2018 - 09/2015
3	Glucose (Dextrose)FDA LinkGeneric 12/2015 - 01/2014
3	EnzymesIBA 09/2015 - 09/2010
3	N(G),N(G')-dimethylarginineIBA 09/2015 - 12/2003
3	3-nitrotyrosineIBA 05/2014 - 11/2005
2	Acetaminophen (Paracetamol)FDA LinkGeneric 09/2022 - 09/2014
2	Metformin (Glucophage)FDA LinkGeneric 06/2022 - 10/2018
2	IsotopesIBA 06/2022 - 06/2019
2	Anti-Bacterial Agents (Antibiotics)IBA 11/2020 - 08/2007
2	AcidsIBA 08/2020 - 11/2009
2	CreatineIBA 06/2020 - 05/2019
2	3,4-dihydroxyphenylglycolIBA 06/2020 - 05/2011
2	CatecholaminesIBA 06/2020 - 12/2013
2	PotassiumIBA 05/2019 - 09/2014
2	Apolipoproteins E (ApoE)IBA 07/2018 - 08/2013
2	Indicators and Reagents (Reagents)IBA 01/2018 - 01/2012
2	Protons (Proton)IBA 01/2018 - 01/2017
2	Surface-Active Agents (Surfactants)IBA 01/2016 - 09/2005
2	Dietary Fats (Dietary Fat)IBA 12/2015 - 05/2014
2	Human Serum Albumin FDA LinkGeneric 09/2015 - 04/2011
2	Urea (Carbamide)FDA LinkGeneric 09/2015 - 12/2006
2	Atorvastatin (Lipitor)FDA Link 04/2015 - 08/2013
2	IonsIBA 09/2014 - 06/2009
2	Oleic Acid (Oleate)IBA 06/2014 - 09/2010
2	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 08/2013 - 04/2006
2	dimethylargininaseIBA 05/2012 - 11/2011
2	dimethylarginineIBA 12/2011 - 11/2011
2	Peroxidase (Myeloperoxidase)IBA 12/2011 - 11/2009
2	Angiotensin IIIBA 04/2005 - 04/2002
2	CholesterolIBA 08/2004 - 05/2004
1	InterleukinsIBA 09/2022
1	AntidotesIBA 09/2022

Therapy/Procedure

7	Therapeutics 01/2022 - 04/2009
3	Kidney Transplantation 03/2019 - 02/2009
3	Transplantation 03/2019 - 09/2015
3	Oral Administration 04/2016 - 04/2009
2	Protein-Restricted Diet (Diet, Protein Restricted) 05/2019 - 05/2012
2	Drug Therapy (Chemotherapy) 02/2003 - 11/2002